Sickle Cell Disease (SCD) is an inherited genetic disorder of the red blood cells with a multi-systemic manifestation and the highest disease burden in Nigeria, where over 150,000 babies are born annually but less than 50% of these survive beyond the first 5years of life due to severe infections. The overall aim is to evaluate a new point-of-care diagnostic with digital transmission of results to a central database and cellphones for subject tracking to improve the turnaround time for diagnosis, specialist clinic registration, and subject tracking with the ultimate goal of providing a platform that can be scaled up for a robust national surveillance program for SCD care.