Maternal recto-vaginal colonization with Group B Streptococcus (GBS) and consequent vertical transmission of resistant bacteria to the newborn predispose neonates to early-onset invasive disease. This project aimed to assess the risk factors of neonatal disease in pregnant women colonized with GBS and antibiotic-resistant Gram-Negative organisms and also the maternal and birth adverse outcomes associated with these organisms.
The objectives of this project are:
- To determine risk factors for colonization, associated perinatal events, evaluate a vertical transmission prevention
- To study the serotype distribution of GBS isolates associated with colonization in mother-newborn dyads
- To characterize the capsular serotype distribution of invasive isolates from infants
- To compare the relative invasive potential of GBS serotypes associated with early-onset disease.
- To study the antibiotic-resistant genes of Gram-Negative isolates associated with colonization in mother-newborn dyads.